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KMID : 0361020000430050493
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 5 p.493 ~ p.500
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Morphologic Changes in Nasal Mucosa of the Rat after Ozone Exposure
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Jeong Jin-Uk
Kim Yong-Min
Rha Ki-Sang
Kim Byung-Kook
Park Chan-Il
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Abstract
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Background and Objectives : Ozone is the principal oxidant pollutant in photochemical
smog. Although ozone-induced pulmonary changes have been morphologically
characterized, effects of ozone on the upper respiratory tract have not been thoroughly
investigated.. The purpose of this study was to investigate the morphological change of
nasal mucosa after acute exposure to ozone.
Material and Methods : Rats are exposed to 0.3, 0.6, 0.9, and 1.2ppm of O3
for 6 hours a day 7 days. Rats were sacrificed 18th after the end of their last exposure.
Nasal mucosa was processed for Hematoxylin/Eosin(H/E) stain and Alcian blue (pH
2.5)/Periodic Acid Schiff (AB/PAS) stain.
Results : Morphological changes such as infiltration of neutrophils, loss of cilia, epithelial
hyperplasia, squamous metaplasia and secretory cell metaplasia were observed and these
changes were more pronounced in the group exposed to high concentration of ozone,
compared with the group exposed to low concentration.
Conclusion : The results of this study may suggest that ozone exposure induces
inflammatory, proliferative, and metaplastic responses in the nasal mucosa.
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KEYWORD
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Ozone, Nasal mucosa, Morphologic changes
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